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Walter K. Schmidt,
WANTED: New students willing to tackle challenging and interesting basic science problems related to human disease (e.g. cancer, aging, and prions).
OUTCOMES: Past lab members have leveraged their training for great positions: click here.
Our lab uses a variety of technical approaches to better
understand how post-translational modifications regulate the function of CaaX-type proteins. These proteins are subject to an ordered series of C-terminal modifications: isoprenylation, proteolysis, and carboxylmethylation (steps 1-3 in figure below). Prominent examples of CaaX
proteins can be found among the Ras family of oncoproteins that are often mutated in cancer.
Standard v. Shunt Pathway: We recently discovered that certain CaaX proteins follow an isoprenylation-only branch of the standard modification pathway that we refer to as the shunt pathway (e.g. see Ydj1p in figure below). Pathway preference appears linked to optimal CaaX protein function. We are determining the pathway followed by various CaaX protein reporters and detailing the consequences of altering their modification preference. These consequences range from altered protein activity, to differential localization, to changes in cellular phenotypes.
Course Related Information
FYOS 1001 resources - The Contributions of Underrepresented Minorities to Today's Understanding of Biology.
GRSC 8010 resources - Graduate Professional Development.
BCMB/CBIO/GENE 8212 resources - Comprehensive Graduate Course in Biochemistry, Molecular Biology, Cell Biology, and Genetics.
Other BCMB courses
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